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Tocotrienol Research

Helps Maintaining Healthy Cholesterol Level

Tocotrienol was found to inhibit cholesterol production in the liver.

Tocotrienol suppresses hepatic HMG-CoA reductase activity that results in the lowering of LDL cholesterol levels.

Tocotrienols which are naturally occurring in palm oil, have been shown to suppress / lower plasma cholesterol in human.

 

Effects On Carotid Atherosclerosis

Medical human research showed that patients with confirmed carotid atherosclerosis, who consumed 240mg of palm based tocotrienol complex per day for 18-36 months had a decrease in the amount of cholesterol plaque in their carotid artery while those receiving placebo did not show such an effect.

Palm based tocotrienol complex protects the ApoE knockout mice against cholesterol build-up and hence prevent arteriosclerosis.

 

Improves Arterial Compliance

Randomized controlled human clinical study shows that self-emulsifying palm tocotrienol complex reduces arterial stiffness after two months of oral supplementation.

 

Effects On Platelet Aggregation

In 2011, Qureshi and his team reported that alpha-tocotrienol and palm tocotrienols (TRF) given intravenously significantly reduced both collagen and ADP-induced platelet aggregation compared to alpha-tocopherol (22%) in a canine study model. (Qureshi AA et al. Lipids Health Dis. 2011 Apr 14;10:58).

Currently, human clinical trial conducted at Ohio State University, led by Prof. Dr. Chandan Sen , demonstrated that Tocomin SupraBio® bioenhanced full spectrum palm tocotrienol complex has potential as an effective anti-thrombotic agent in humans (click to watch the video interview to learn more).

 

Neuroprotection

Based on on-going NIH-funded study and in collaboration with the Ohio State University Medical Center - Prof. Chandan Sen has published several peer-reviewed papers which proved that alpha-tocotrienol is the most potent in supporting brain function in stroke-related events.

 

Certain Cancers & Tumors

Palm based tocotrienols were shown to inhibit human breast cancer cells irrespective of estrogen receptor status. Tocopherol has no effect at all on human breast cancer cells.

Alpha-tocotrienol and gamma-tocotrienol have been shown to prolong the life span of cancer-infected mice.

Gamma-tocotrienol is 3 times more potent in inhibiting growth of human breast cancer cultured cells than Tamoxifen.

Published research from the Eastern Tennessee University and MD Anderson Cancer Center (Texas) revealed that gamma-tocotrienol was the most potent in inhibiting prostate cancer cells.

 

Potent Natural Super-Antioxidant

Alpha-tocotrienol has been shown to be 40 - 60 times more potent than alpha-tocopherol as an antioxidant in the prevention of lipid peroxidation.

Effective antioxidant in the prevention of protein oxidation and lipid peroxidation after strenous exercise for athletes, joggers and body builders.

 

Anti- Aging / Cosmetics and Personal Care

Tocotrienol preferentially accumulates at the stratum corneum of the skin. Being a more potent antioxidant, the tocotrienols neutralizes free radicals at a faster rate and hence protect tocopherols.

Tocotrienols topically applied onto the skin was found to penetrate rapidly through the skin and the highest concentrations are found in the uppermost 5 microns.

Tocotrienol-treated skin contained Vitamin E at concentration 7-30 fold higher than control values.

 
Disclaimer: The above are some of the scientific research done on palm tocotrienol complex. 

These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease.