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Cholesterol Reduction How it works ?
  • Inhibit cholesterol production in the liver, thereby lowering total blood cholesterol. (Ref 1.15,1.19)
  • Alpha tocotrienol suppresses hepatic HMG-CoA reductase activity that results in the lowering of LDL cholesterol levels.  (Ref 1.10)
  • Tocotrienols which are naturally occurring in palm oil have been shown to suppress lower plasma cholesterol in human. (Ref 1.20)
  • Combination of gamma-tocotrienol and alpha-tocopherol is found as a potential hypolipemic agent in hyperlipemic humans at atherogenic risk.  (Ref 1.10)
  • Tocotrienols inhibit cholesterogenesis by suppressing HMG-CoA reductase. (Ref 1.13)


Reversing Arteriosclerosis How it works ?
  • Reverses arterial blockage (carotid arteriosclerosis), hence reducing the risk factors for cardio-vascular diseases such as arteriosclerosis and stroke. Palm based tocotrienols is the first and natural compound to be shown by human study, to have the ability to reverse arteriosclerosis. (Ref 2.5,2.6)
  • Medical human research showed that patients with confirmed carotid arteriosclerosis, who consumed 240mg of palm based tocotrienols/ day for 18-36 months had a decrease in the amount of cholesterol plaque in their carotid artery while those receiving placebo did not show such an effect. (Ref 2.5,2.6)
  • Palm based tocotrienol protects the ApoE knockout mice against cholesterol build-up and hence prevent arteriosclerosis. (Ref 2.10)
  


Protection Against Ischemia/Reperfusion Heart Injury How it works ?
  • Medical study suggests that palm based tocotrienols were more efficient than alpha-tocopherol alone in the protection of the heart against oxidative stress induced by ischemic reperfusion. (Ref 2.3)


Inhibit of Platelet Aggregation How it works ?
  • Delta-tocotrienol was significantly more potent than the alpha and gamma-tocotrienols, in the inhibition of platelet aggregation.
  • Palm based tocotrienols may serve as an antithrombotic agent by decreasing platelet aggregation significantly. (Ref 2.1)


Anti-cancer and Tumour Suppresive How it works ?
  • Palm based tocotrienols had shown to inhibit human breast cancer cells irrespective of estrogen receptor status. Tocopherol has no effect at all on human breast cancer cells. (Ref 5.3)
  • Delta - tocotrienol was found to be the most effective tocotrienols in inducing apoptosis (cell death) in estrogen-responsive and estrogen-nonresponsive human breast cancer cells. (Ref 5.13)
  • Confer anti-cancer properties. (Ref 5.4)
  • Inhibit tumor growth of certain cancers. (Ref 7.5, 5.10, 5.12, 5.11)
  • Alpha-tocotrienol and gamma-tocotrienol have shown to prolong the life span of cancer-infected mice.  (Ref 7.1)
  • Gamma-tocotrienol is 3 times more potent in inhibiting growth of human breast cancer cultured cells than Tamoxifen. (Ref 5.7,5.8)


Potent Natural Super - Antioxidant  How it works ?
  • Alpha-tocotrienol has been shown to be 40 - 60 times more potent than alpha-tocopherol as an antioxidant in the prevention of lipid peroxidation.  (Ref 4.1)
  • Delta-tocotrienol is the most potent antioxidant (highest antioxidant potency) of all commercially available tocotrienols and has been shown to be the most effective tocotrienol in inhibiting human breast cancer and liver cancer cells. (Ref 7.5)
  • Effective antioxidant in the prevention of protein oxidation and lipid peroxidation after strenous exercise for athletes, joggers and body builders. (Ref 4.11, 4.8)


Anti - Aging / Cosmetics and Personal Care How it works ?
  • Preferentially accumulates at the strata corneum of the skin. First line of defense against free radicals generated in the skin by UV/ozone rays. Prevention of skin aging and damage by oxidative rays. Being a more potent antioxidant, the tocotrienols neutralizes free radicals at a faster rate and hence protect tocopherols. (Ref 10.4, 10.5)
  • Protection against UV-induced skin damage and skin aging. (Ref 10.4, 10.5)
  • Tocotrienols topically applied onto the skin was found to penetrate rapidly through the skin and the highest concentrations are found in the uppermost 5 microns. (Ref 4.17, 10.3, 10.4, 10.5)
  • Tocotrienol-treated skin contained Vitamin E at concentration 7-30 fold higher than control values. (Ref 10.2)
  • Tocotrienol augments the efficacy of sunscreens containing compounds that reduce penetration of or absorb ultraviolet radiation. (Ref 10.4, 10.5)


Lower Blood Pressure
  • Palm gamma-tocotrienol has ability to prevent development of increased blood pressure in Spontaneously Hypertensive Rats (SHR) after 3 months supplementation. (Ref 3.2, 3.1)